The type I interferons present in humans are IFN-α, IFN-β, IFN-ε, IFN-κ and IFN-ω. This use is approved for the Sylatron brand of peginterferon alfa-2b. Cite. Recombinant interferon alfa given subcutaneously three times per week for 1 year yields a 10% complete response rate and an 80% overall response rate. for a few hours after administration as well as chronic fatigue, skin rashes, alopecia, and autoimmune reactions. Available for licensing are hybrid interferon alpha (INF-alpha) polypeptides constructed by combinations of INFalpha21b and INFalpha2c, and mutants of these hybrids. Interferon Alfa-2a suppresses antibody formation through an effect on B-lymphocytes and inhibits onset of delayed hypersensitivity. Methods Retrospective case series. Although donated human plasma is screened, tested . Adult Indications and Dosage Interferon alfa-2b, recombinant For Injection WARNING Alpha interferons, including INTRON A, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious. increased risk of bleeding due to clotting disorder decreased blood platelets low levels of white blood cells low levels of a type of white blood cell called neutrophils mental problems suicidal. Determine the objective response rate in patients with metastatic renal clear cell carcinoma treated with interferon alfa-1b. They are produced by fibroblasts and monocytes. 1 888 391 5441. Kinetic differences in the induction of interferon stimulated genes by interferon-alpha and interleukin 28B are altered by infection with hepatitis C virus. Peginterferon alfa-2b is also approved to treat chronic hepatitis C. This use is approved for the PEG-Intron brand of peginterferon alfa-2b. 1999: Interferon alfa for chronic hepatitis C infection . Indications and Dosage. Call your doctor at once if you have: unusual changes in mood or behavior, chest pain, trouble breathing, sudden numbness or weakness, or signs of infection (fever, chills, cough with mucus, or burning when you urinate). Newer formulations of interferon alpha, aimed at . Patients receive interferon alfa-1b subcutaneously daily. Has the same actions (antiviral, immunomodulating, antiproliferative) as interferon alfa-2a. Indications and Usage. Therapeutic Effects. L03AB01 - Interferon Alfa Natural PLEASE, BE CAREFUL! Abstract. Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Bioferon (Interferon Alfa-2b . Suicide or suicidal thoughts, thoughts of hurting others, depression, forceful actions, hallucinations, and other mood or behavior problems have happened during treatment and within 6 months after the last dose. The drug frequently produces an influenza-like syndrome early in the course of treatment. Currently it is considered a second-line drug for this condition. Tell all of your health care providers that you take Interferon Alfa 2b Cassara. Meixong J. Semin Oncol. Has the same actions (antiviral, immunomodulating, antiproliferative) as interferon alfa-2a. Abstract. Indications and dose. 2009/12/18. It inhibits replication of a wide range of RNA and DNA viruses. Blood. Peginterferon alfa-2b is indicated in combination . In addition, it is indicated for chronic phase, Philadelphia chromosome (Ph) positive chronic myelogenous leukemia ( CML) patients who are minimally pretreated (within 1 year of diagnosis). INTRON A recombinant for Injection has been classified as an alpha interferon and is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques. Interferon alfa-n3 is made from human plasma (part of the blood) and may contain viruses and other infectious agents that can cause disease. It inhibits replication of a wide range of RNA and DNA viruses. Interferon Alpha Hybrids. Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. 2014/09/30. Interferon alpha is a drug derived from human cells that modulates the immune system, fights certain infections, and has anti-tumor activity. The drug interferon alfa-2b is obtained by recombinant DNA technology from a strain of Escherichia coli bearing an interferon alfa-2b gene from human leukocytes. Heise, R. et al. Peginterferon is a combination of interferon and polyethylene glycol, which helps the interferon stay active in your body for a longer period of time. INTRON A recombinant for Injection has been classified as an alpha interferon and is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques. However, despite its clinical efficacy, interferon alfa is associated with a significant toxicity profile. Severe pre-existing cardiac disease, severe renal, hepatic or myeloid dysfunction, epilepsy, and/or compromised CNS function are contraindications. It inhibits replication of a wide range of RNA and DNA viruses. Recent advances have led to Food and Drug Administration approval of five clinical indications for IFN. Brand Names: Intron A. Interferon alfa-2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, Kaposi's sarcoma caused by AIDS, and certain types of genital warts . Overview. It is used to prevent melanoma from coming back after it has been removed by surgery. Precertification of interferons for the multiple sclerosis indication are required of all Aetna participating providers and members in applicable plan designs. For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. Peginterferon alfa-2a is indicated, in combination with ribavirin, for the treatment of chronic hepatitis C (HCV) in patients 5 years and older with compensated liver disease, including patients with HCV and HIV coinfection (with a CD4 count greater than 100 cells/mm 3 ). Therapy of chronic 10. Interferon Alfa-2a suppresses antibody formation through an effect on B-lymphocytes and inhibits onset of delayed hypersensitivity. Interferon alfa-2b injection and ribavirin combination may cause a dry mouth. Strength - 5MIU/1.0mL. Interferon Alfa-2a has antiviral, antitumour and immunomodulatory activity. 1 888 391 5441. The information provided in Therapeutic indications of Bioferon (Interferon Alfa-2b) is based on data of another medicine with exactly the same composition as the Bioferon (Interferon Alfa-2b). Strander H. Interferon treatment of . It is useful in treating polycythemia vera, a form of neoplasm. Signs of liver damage, such as dark urine, feeling tired, loss of appetite, upset stomach or stomach pain, light-colored stools, vomiting, or yellow skin or eyes Signs of a serious skin reaction such as red, swollen, blistered, or peeling skin The following symptoms require medical attention, but are not emergency situations. Interferon alfa also has been reported to improve MPN-related symptoms, including a reduction in paresthesia and erythromelalgia in PV [ 8, 9 ]. Hepatology. It also exerts antiproliferative effects on normal and malignant cells. Adult: 1 million IU into each lesion (Max 5 lesions per treatment course) 3 times weekly (every other day) for 3 weeks; repeat after 12-16 weeks as needed. Interferon alfa ( INN) or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the leukocyte fraction of human blood following induction with Sendai virus. Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Interferon Alfa 2b Cassara directly . Drug Information on interferon alfa-n3 includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Crystal of recombinant interferon with altered spatial configuration, three-dimensional structure and uses thereof. Interferon alfa is approved for hairy-cell leukemia, condyloma acuminatum, Kaposi's sarcoma in the acquired immunodeficiency syndrome, and non-A, non-B (type C) viral hepatitis. OUTLINE: This is an open-label study. In general, type I interferons are produced when the body recognizes a virus that has invaded it. Interferon alfa-2a is FDA approved to treat people who have hairy cell leukemia and Philadelphia chromosome positive chronic myeloid leukemia . Manufacturer Name - Intas Pharmaceuticals Ltd. What is Interferon Alfa 2B and what it is used for: Interferon Alfa 2B specifically is an antiviral or antineoplastic medication used for the treatment of: Chronic Hepatitis C / Chronic Hepatitis B. A major cytogenetic response is defined by < 34 % Ph+ leukaemic cells in the bone marrow, whereas a minor response is ≥ 34 %, but < 90 % Ph+ cells in the marrow.Combination therapyThe combination of interferon alfa-2b and cytarabine (Ara-C) administered during the first 12 months of treatment has been demonstrated to significantly increase . . Due to the high cost and specific approved indications, MO HealthNet will impose clinical Interferon alfa-2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, Kaposi's sarcoma caused by AIDS, and certain types of genital warts.Interferon alfa-2b is also used to treat chronic hepatitis B or C in adults, and to treat chronic hepatitis B in children who are at least 1 year old.. Interferon alfa-2b may also be used for purposes not listed in this medication . It also exerts antiproliferative effects on normal and malignant cells. Interferon alfa-2a has antiviral, antitumour and immunomodulatory activity. . Peginterferon alfa-2a is in a class of medications called interferons. They may also be synthetic versions of these substances. Austin: University of Texas Press, 1986; 13 (suppl 2):29-35. System: A Current Review. Interferon is contraindicated in patients with known hypersensitivity to alpha interferons, to E coli-derived products, or to any component of the product. Should not be used in the neonatal-period. Roferon-A (interferon alfa-2a, recombinant) is indicated for the treatment of chronic hepatitis C and hairy cell leukemia in patients 18 years of age or older. [16] Interferon-beta In addition, peginterferon alfa-2a is indicated in . In Germany recombinant interferon alpha 2a and 2b are licensed for the indication HIV-associated Kaposi's sarcoma and cutaneous T-cell lymphoma (interferon alpha 2a), and in the USA even for . Polyethylene glycol-conjugated ('pegylated') derivatives of interferon alfa (peginterferon alfa-2a and peginterferon alfa-2b) are available; pegylation increases the persistence of the interferon in the blood. Request PDF | On Nov 1, 2006, T. Hadad and others published Interféron alpha : Indications en médecine interne | Find, read and cite all the research you need on ResearchGate Indications. . Interferon a (human leukocyte protein moiety reduced). The Interferon treatment of chronic granulocytic leukemia. It also exerts antiproliferative effects on normal and malignant cells. Find patient medical information for Interferon Alfa-2B Injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. , et al Results of the Myeloproliferative Neoplasms - Research Consortium (MPN-RC) 112 randomized trial of pegylated interferon alfa-2a (PEG) versus hydroxyurea (HU) therapy for the treatment of high risk polycythemia vera (PV) and high risk essential thrombocythemia (ET) [abstract]. Interferon alfa-2a. Interferon alfa-2b is a . Uses Advanced search. Interferon alfa-2b injection is used to treat hepatitis B and C, lymphoma (lymph node cancer), malignant melanoma (skin cancer), genital warts, hairy cell leukemia (blood cell cancer), and Kaposi sarcoma (AIDS-related tumor). Interferon alfa-2b can cause life-threatening infections, autoimmune disorders, serious mood or behavior problems, or a stroke. bruising, bleeding, pain, redness, swelling, or irritation in the place you injected interferon alfa-2b muscle pain change in ability to taste hair loss dizziness dry mouth concentration problems feeling cold or hot weight changes skin changes Some side effects can be serious. [14] There are also reports of anorexia and erectile dysfunction. Interferon alfa-2b (Intron A) What are some things I need to know or do while I take Interferon Alfa 2b Cassara? Patent: US-8846025-B2: Inventor: WEI GUANGWEN (CN) WANG DACHENG (CN) Assignee: WEI GUANGWEN (CN) WANG DACHENG (CN) Dates: Grant . Essentially, when confronted with a virus, each cell shoots an emergency flare of interferon to tell the immune system to marshall its defenses. Active children should be protected from infection and injury. Exceptions include interferon alfa-2b, azathioprine, cyclosporine, tacrolimus, and palivizumab which should be used cautiously because of their toxic effects on GI, renal, hematological, or central nervous system. After binding to the interferon alfa receptor (IFNAR), Besremi initiates a downstream signaling cascade that reduces blood cell production. 1987;337-346. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Interferon alpha (INF-alpha)--In systemic diseases, most indications for INF-alpha result from its effect on haematological or hepatological manifestations. Pegylated Interferon Alpha-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). This includes your doctors, nurses, pharmacists, and dentists. 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